Why is precision so important when getting feminizing HRT?

A: By precision I mean precise dosing & precise patterning.  Individual persons vary widely from one to the other in terms of their rates of excretion for estrogen.  So a one size fits all approach makes no sense.  And the balance between estrogen & progesterone dosages also matters, varying with different types of patients.  Beyond hormonal balancing there is the matter of hormonal pattern, whether stable or erratic & whether there are many dips & surges in hormonal levels.  Many important medical problems can be driven by erratic hormone levels or by unsuitable balances between the hormones so this idea of precision is critical to obtaining a safer yet more effective source of hormones.