A:  Indeed, when feminizing therapy is administered precisely, with the right balances, dosage & pattern & via optimal delivery systems, mental & emotional complications can be avoided, in fact mental benefits rather than side-effects may ensue.  Some illegal injectables from South & Central America often trigger mood swings, anger, even irrational behavior bordering on psychosis. Estrogen protects women from schizophrenia & bipolar disorder.  Patients with a history of both these conditions will often improve dramatically on precision HRT, with clearer thinking and less need for heavy handed drug therapy. All the more reason to seek treatment from a trained endocrinologist who is expert in hormonal care rather than a practitioner flying by the seat of his or her pants.